Nanozymes of Ni0.5Fe0.5S2 Mediated Synergetic Antitumor Treatment

作者：Zeng, Jia; Wang, Yufeng; Wu, Jingpeng; Wang, Huiwen; Lu, Junrong; Li, Shijie; He, Dongfeng^*

来源：ChemNanoMat, 2022, 8(6): e202200090.

DOI：10.1002/cnma.202200090

• Nanozymes
• phototherapy
• antitumor

How to establish a multi-modality oncotherapy method on the basis of single matter mediated utilization of tumor endogenous substances is very promising for efficient antitumor treatment. In this work, we have designed a metallic Ni0.5Fe0.5S2 nanosphere for synergetic chemodynamic/photodynamic/photothermal antitumor treatments. Under NIR excitation, a remarkable photothermal effect could be generated by Ni0.5Fe0.5S2 for realizing the photothermal therapy. Meanwhile, Ni0.5Fe0.5S2 could also trigger formation of reactive oxygen species (ROS) via transformation of tumor-site oxygen for the further photodynamic therapy. Furthermore, peroxidase-like property of Ni0.5Fe0.5S2 favors the catalysis of endogenous H2O2 into hydroxyl radical to achieve a chemodynamic therapy. As a result, the on-site tumor hyperthermia, tumor-site oxygen and H2O2 conversion are worked for the antitumor action. On the merits of above synergistic effect, a better antitumor outcome was confirmed as compared with any single antitumor action, and complete removal of solid tumor under a relative lower temperature has been accomplished.

• 单位
  哈尔滨医科大学