Nicotinamide mononucleotide (NMN) and NMN-rich product supplementation alleviate p-chlorophenylalanine-induced sleep disorders

作者：Shen, Chun-Yan^*; Li, Xiao-Yi; Ma, Pan-Yu; Li, Hong-Lei; Xiao, Bing; Cai, Wei-Feng; Xing, Xue-Feng^*

来源：Journal of Functional Foods, 2022, 91: 105031.

DOI：10.1016/j.jff.2022.105031

• Nicotinamide mononucleotide
• Insomnia
• Sedative
• Hypnotic

Nicotinamide mononucleotide (NMN) has various beneficial effects, while its protective effects against insomnia remain elusive. NMN and NMN-rich products (NMNP) alleviated depression-like behavior and stimulated sodium pentobarbital-induced sleeping of p-chlorophenylalanine (PCPA)-induced mice. NMN and NMNP restored brain damages and reduced oxidative stress. NAD(+) concentration, silent mating type information regulation 2 homolog 1 (SIRT1) expression, 5-hydroxytryptamine (5-HT) level and 5-HT1A expression in hippocampus of PCPA-induced mice were up-regulated by NMN and NMNP. NMN and NMNP also modulated gamma-gminobutyric acid (GABA) and glutamate production by increasing GABA(A) receptor alpha 2 and glutamic acid decarboxylase 65/67 expression. NMNP, composed 23.9% of NMN, was more powerful than NMN in activating GABAergic system. NMN and NMNP exhibited prominent enhancement on immune system through boosting NO secretion and IL-1 beta expression. These data suggested that NMN and NMNP exerted sedative effects via regulating oxidative stress, SIRT1 pathway, 5-HTergic, GABAergic and immune systems simultaneously.

• 单位
  南方医科大学