Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO3)3middot9H2O

作者:Liu, Kai; Meng, Jiaolong; Jiang, Xuefeng*
来源:ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023, 27(7): 1198-1202.
DOI:10.1021/acs.oprd.2c00390

摘要

Sulfoxides, as an essential pivot, are commonly found in pharmaceuticals and bulk chemicals. A practical synthetic protocol is depicted via application of readily obtainable Fe(NO3)3 center dot 9H2O as a catalyst and oxygen as a green oxidant for selective oxidation from thioethers to sulfoxides under ecofriendly and mild conditions. Various sulfoxides are all achieved in gram-scale with superior selectivity and efficiency. This protocol showcases broad-spectrum functional group compatibility, offering efficient access to sulfoxide construction for drug discovery and process optimization.

  • 单位
    南开大学; 中国科学院