Highly integrated watch for noninvasive continual glucose monitoring

作者：Chang, Tianrui; Li, Hu; Zhang, Nianrong; Jiang, Xinran; Yu, Xinge; Yang, Qingde; Jin, Zhiyuan; Meng, Hua^*; Chang, Lingqian^*

来源：Microsystems & Nanoengineering, 2022, 8(1): 25.

DOI：10.1038/s41378-022-00355-5

• REVERSE IONTOPHORESIS
• SENSORS

This article reports a highly integrated watch for noninvasive continual blood glucose monitoring. The watch employs a Nafion-coated flexible electrochemical sensor patch fixed on the watchband to obtain interstitial fluid (ISF) transdermally at the wrist. This reverse iontophoresis-based extraction method eliminates the pain and inconvenience that traditional fingerstick blood tests pose in diabetic patients' lives, making continual blood glucose monitoring practical and easy. All electronic modules, including a rechargeable power source and other modules for signal processing and wireless transmission, are integrated onto a watch face-sized printed circuit board (PCB), enabling comfortable wearing of this continual glucose monitor. Real-time blood glucose levels are displayed on the LED screen of the watch and can also be checked with the smartphone user interface. With 23 volunteers, the watch demonstrated 84.34% clinical accuracy in the Clarke error grid analysis (zones A + B). In the near future, commercial products could be developed based on this lab-made prototype to provide the public with noninvasive continual glucose monitoring.

• 单位
  北京航空航天大学