An investigation over the impact of conventional Chinese bone setting to cartilage and the VEGF expression in cartilage cells in rats with knee osteoarthritis disease

作者：Ma Bitao; Jin Lilun; Liu Xiuli; Teng Weiran^*

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(5): 5552-5558.

• Chinese bone setting
• osteoarthritis
• cartilage
• vascular endothelial growth factor

The conventional Chinese bone setting, named Xiao Yu San Plaster has been used for treating knee osteoarthritis for hundreds of years and achieved dramatic effects. However, very few work has been done to investigate the impact these bones settings experimentally or pre-clinically. In this work, we investigated the impact of this bone setting on cartilage tissue structure. In particular, we also studied the influence of this bone setting on VEGF metabolism in the cartilage cells. To illustrate the treatment efficacy, an FDA approved medicine, Voltaren Gel, was employed as a control group. Morphological observation and immunohistochemical staining demonstrated that the bone setting improved the disease to a degree comparable to Voltaren Gel. This study illustrated the potency of the Chinese bone setting in treating knee osteoarthritis disease, and partially revealed the mechanism behind the treatment.

• 单位
  上海交通大学