Bio-Inspired Fractal Robust Hydrogel Catheter for Intra-Abdominal Sepsis Management

作者：Wang, Lichun; Li, Wenzhao; Li, Min^*; Lai, Puxiang; Yang, Chunhua^*; Wang, Hui; Ma, Bo^*; Huang, Rongkang^*; Zu, Yan^*

来源：Advanced Science, 2023.

DOI：10.1002/advs.202303090

• bio-inspired
• biomaterials
• drainage catheter
• intra-abdominal sepsis
• porous hydrogel

To deal with intra-abdominal sepsis, one of the major global causes of death in hospitalized patients, efficient abscess drainage is crucial. Despite decades of advances, traditional catheters have demonstrated poor drainage and absorption properties due to their simple tubular structures and their dense nonporous surface. Herein, inspired by porous sponges and fractal roots, a multifaceted hydrogel catheter with effective drainage, absorptive, and robust properties, is presented. Its unique fractal structures provide extensive internal branching and a high specific surface area for effective drainage, while the hierarchical porous structures provide a wide range of absorption capabilities. Additionally, its distinctive multi-interpenetration network maintains robust and appropriate mechanical properties, even after absorption multiple times of liquid and mechanical disturbance, allowing for intact removal from the abdominal cavity without harm to the animal in vivo. Besides, the loaded antimicrobial peptides are capable of being released in situ to inhibit the potential for infections. In vivo experiments have demonstrated that this hydrogel catheter efficiently removes lethal abscesses and improves survival. It is believed that this innovative and practical catheter will create a future precedent for hydrogel drainage devices for more effective management of intra-abdominal sepsis. @@@ Inspired by porous sponges and fractal roots, a multifaceted hydrogel catheter is developed with effective drainage, absorptive, and robust properties for intra-abdominal sepsis management. Its fractal design ensures efficient internal branching and high surface area for drainage, while hierarchical pores offer broad absorption. Its multi-interpenetration network maintains robust properties and loaded antimicrobial peptides can be released to prevent infections.image

• 单位
  6; 中山大学; y; 南方医科大学; 中国科学院研究生院