科研之友
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摘要
Aims: We aimed to investigate the relationship of dietary zinc intake with new-onset diabetes among Chinese adults. @@@ Materials and Methods: A total of 16 257 participants who were free of diabetes at baseline from the China Health and Nutrition Survey were included. Dietary intake was measured by 3 consecutive 24-hour dietary recalls combined with a household food inventory. Participants with self-reported physician-diagnosed diabetes, or fasting glucose >= 7.0 mmol/L, or glycated hemoglobin >= 6.5% during the follow-up were defined as having new-onset diabetes. @@@ Results: A total of 1097 participants developed new-onset diabetes during a median follow-up duration of 9.0 years. Overall, the association between dietary zinc intake and new-onset diabetes followed a U-shape (P for nonlinearity < 0.001). The risk of new-onset diabetes was significantly lower in participants with zinc intake < 9.1 mg/day (per mg/day: hazard ratio [Hr], 0.73; 95% CI, 0.60-0.88), and higher in those with zinc intake >= 9.1 mg/ day (per mg/day: HR, 1.10; 95% CI, 1.07-1.13). Consistently, when dietary zinc intake was assessed as deciles, compared with those in deciles 2-8 (8.9 -<12.2 mg/day), the risk of new-onset diabetes was higher for decile 1 (<8.9 mg/day: HR, 1.29; 95% CI, 1.04-1.62), and deciles 9 to 10 (>= 12.2 mg/day: HR, 1.62; 95% CI, 1.38-1.90). Similar U-shaped relations were found for plant-derived or animal-derived zinc intake with new-onset diabetes (all P for nonlinearity <0.001). @@@ Conclusions: There was a U-shaped association between dietary zinc intake and newonset diabetes in general Chinese adults, with an inflection point at about 9.1 mg/day.
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单位安徽医科大学; 南方医科大学
