Drug delivery with Mn-doped MoO2 for photothermal-enhanced chemotherapy in fighting cancers

摘要

Although chemotherapy has been intensively applied in cancer treatments, its inadequate therapeutic efficacy and severe side effects are still under constant concerns. Nanoplatforms used as anti-tumor drug delivery system (DDS) have attracted tremendous attentions owing to their various intriguing properties. Herein, Mn-doped MoO2 nanoparticles coated with ZrO2 and capped with Bi2O3 have been designed as a DDS, namely MMZB. MMZB possesses good magnetic properties, great photothermal conversion ability, sensitive tumor microenvironment (TME) responsiveness, and good biocompatibility in hemocompatibility in vitro. Thus, MMZB has been utilized to load the chemotherapeutic agent daunomycin (DNM) (MMZB@DNM) for chemo-photothermal combined therapy. MMZB@DNM demonstrates a more impressive anti-cancer effect than the individual photothermal or chemotherapy both in vitro and in vivo. Furthermore, the analysis of tumor specimen sections and serum levels after the treatment indicates negligible side effects for MMZB@DNM in vivo. This contribution provides a valuable concept in designing therapeutic agents for achieving significantly enhanced tumor treatments, which benefits from the synergistic combination of chemotherapy and photothermal therapy in one single nanoagent.

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