Asymmetric Formal [3+2] Cycloaddition Reactions of 3-Isothio-cyanato Oxindoles: an Update

作者：Tan, Fen; He, Xiao-Yu; Yang, Qing-Qing^*; Zou, You-Quan^*

来源：Synlett, 2023, 34(4): 301-313.

DOI：10.1055/a-1986-7969

• spirooxindoles
• 3-isothiocyanato oxindoles
• asymmetric synthesis
• organocatalysis
• Lewis acid catalysis
• cycloaddition reaction

3-Isothiocyanato oxindoles are a class of important building blocks which have been widely used in the synthesis of structurally diverse enantioenriched spirooxindoles. In this short review, it is attempted to cover the recent synthetic aspects of 3-isothiocyanato oxindoles participated cascade cyclizations in the last few years (i.e., from 2017 to 2022), with an emphasis on formal [3+2] cycloaddition reactions. 1 Introduction 2 Organocatalyzed Formal [3+2] Cycloaddition of 3-Isothiocyanato Oxindoles 3 Lewis Acid Catalyzed Formal [3+2] Cycloaddition of 3-Isothiocyanato Oxindoles 4 Conclusions

• 单位
  武汉大学