2D Nanozymes Modulate Gut Microbiota and T-Cell Differentiation for Inflammatory Bowel Disease Management

摘要

Intestinal commensal microbiota dysbiosis and immune dysfunction are significant exacerbating factors in inflammatory bowel disease (IBD). To address these problems, Pluronic F-127-coated tungsten diselenide (WSe2@F127) nanozymes are developed by simple liquid-phase exfoliation. The abundant valence transitions of elemental selenium (Se2-/Se4+) and tungsten (W4+/W6+) enable the obtained WSe2@F127 nanozymes to eliminate reactive oxygen/nitrogen species. In addition, the released tungsten ions are capable of inhibiting the proliferation of Escherichia coli. In a model of dextran sodium sulfate-induced colitis, WSe2@F127 nanozymes modulate the gut microbiota by increasing the abundance of bacteria S24-7 and significantly reducing the abundance of Enterobacteriaceae. Moreover, WSe2@F127 nanozymes inhibit T-cell differentiation and improve intestinal immune barrier function in a model of Crohn's disease. The WSe2@F127 nanozymes effectively alleviate IBD by reducing oxidative stress damage, modulating intestinal microbial populations, and remodeling the immune barrier. @@@ Orally administered tungsten diselenide nanozymes easily reach the site of colonic inflammation. The tungsten diselenide nanozymes scavenge reactive oxygen/nitrogen species and the released tungsten ions further inhibit the proliferation of Enterobacteriaceae. In addition, the nanozymes inhibit T-cell differentiation by regulating reactive oxygen species, thus alleviating inflammatory bowel disease.image

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