Aptamer functionalization and high-contrast reversible dual-color photoswitching fluorescence of polymeric nanoparticles for latent fingerprints imaging

作者：Zhang, Peisheng; Xue, Mingju; Lin, Zhong; Yang, Heping; Zhang, Chonghua^*; Cui, Jiaxi; Chen, Jian^*

来源：Sensors and Actuators, B: Chemical , 2022, 367: 132049.

DOI：10.1016/j.snb.2022.132049

• Polymer nanoparticles
• Photoswitching
• Dual-color
• Fluorescent imaging
• Latent fingerprints

Exploiting the intelligent stimuli-responsive fluorescent materials, which can selectively recognize lysozyme in fingerprints and enable high-contrast imaging, is still a challenge in latent fingerprints (LFPs) detection. Herein, based on Fluorescence Resonance Energy Transfer (FRET) mechanism, aptamer functionalization and highcontrast reversible dual-color photoswitching fluorescence of polymeric nanoparticles (LBA-RPFPNs) have been successfully constructed for efficient imaging of LFPs. Experiments results showed that LBA-RPFPNs displayed good water dispersibility, fast photo-responsiveness, favorable photoreversibility and good long-term stability. Of note, the aptamer possessed the ability of LBA-RPFPNs to target lysozyme in LFPs, thus realizing the selectivity of LFPs. Furthermore, the fluorescence of LBA-RPFPNs was reversibly switched between green and red through UV/visible light, achieving for high-contrast imaging of LFPs. This strategy provides good potential in disclosing the valuable information within LFPs.

• 单位
  1; 电子科技大学; 湖南科技大学