Long noncoding RNA HAND2-AS1: A crucial regulator of malignancy

作者：Huang, Ziyue; Wang, Zhensheng; Xia, Haoming; Ge, Ziqiang; Yu, Liang; Li, Jiehan; Bao, Haolin; Liang, Zixin; Cui, Yunfu^*; Xu, Yi^*

来源：Clinica Chimica Acta, 2023, 539: 162-169.

DOI：10.1016/j.cca.2022.12.010

• LncRNAs
• HAND2-AS1
• Tumors
• Targeted therapy

Long non-coding RNAs (LncRNAs) are single-stranded RNAs over 200 nucleotides in length that have no protein coding function and have long been considered non-functional by-products of transcription. Recent studies have shown that dysregulation of lncRNAs may be involved in the malignant biological behavior of tumors. Targeted regulation of lncRNAs has become a research focus of anti-tumor treatment. LncRNAs heart and neural crest derivatives expressed 2 antisense RNA 1 (HAND2-AS1) was down-regulated in various tumors and can be used as a critical tumor regulator to modulate tumor cells proliferation, apoptosis, metastasis, invasion, metabolism and drug resistance. Additionally, aberrantly expressed HAND2-AS1 was closely related to the clinical pathological characteristics of cancer patients and serve as a promising tumor diagnostic and prognostic biomarker. This article aims to review the roles of HAND2-AS1 in tumorigenesis and development, as well as the underlying molecular mechanisms and clinical significance.

• 单位
  y; 哈尔滨医科大学