Isoreticular Series of Two-Dimensional Covalent Organic Frameworks with the kgd Topology and Controllable Micropores

Authors：Li, Liuxiao; Yun, Qinbai; Zhu, Chongzhi; Sheng, Guan; Guo, Jun; Chen, Bo; Zhao, Meiting; Zhang, Zhicheng; Lai, Zhuangchai; Zhang, Xiao; Peng, Yongwu^*; Zhu, Yihan^*; Zhang, Hua^*

Source：Journal of the American Chemical Society, 2022, 144(14): 6475-6482.

DOI：10.1021/jacs.2c01199

• CRYSTALLINE
• CONSTRUCTION
• SURFACE
• KINDS
• COF

Two-dimensional (2D) covalent organic frame-works (COFs) possess designable pore architectures but limitedframework topologies. Until now, 2D COFs adopting thekgdtopology with ordered and rhombic pore geometry have rarelybeen reported. Here, an isoreticular series of 2D COFs with thekgdtopologyandcontrollableporesizeissynthesizedbyemploying aC6-symmetric aldehyde,i.e., hexa(4-formylphenyl)-benzene (HFPB), andC3-symmetric aminesi.e., tris(4-aminophenyl)amine (TAPA), tris(4-aminophenyl)trazine(TAPT), and 1,3,5-tris[4-amino(1,1-biphenyl-4-yl)]benzene(TABPB), as building units, referred to as HFPB-TAPA,HFPB-TAPT, and HFPB-TABPB, respectively. The microporedimension down to 6.7 A is achieved in HFPB-TAPA, which isamong the smallest pore size of reported 2D COFs. Impressively, both the in-plane network and stacking sequence of the 2D COFscan be clearly observed by low-dose electron microscopy. Integrating the uniquekgdtopology with small rhombic micropores, these2D COFs are endowed with both short molecular diffusion length and favorable host-guest interaction, exhibiting potential for drugdelivery with high loading and good release control of ibuprofen

• Institution
  南阳理工学院; 浙江工业大学; 天津大学