Rh(III)-Catalyzed Dienylation and Cyclopropylation of 1,2,3-Benzotriazinones with Alkylidenecyclopropanes

作者：Liu, Yan-Zhi; Zeng, Yao-Fu^*; Wei, Jiaohang; Xiao, Lin; Shu, Bing; Song, Jia-Lin; Zou, Wen-Xuan; Shen, Dan-Ting; Chen, Shao-Yong; Zheng, Yi-Chuan; Zhang, Shang-Shi^*

来源：Organic Letters, 2023, 25(28): 5179-5184.

DOI：10.1021/acs.orglett.3c01596

• C-H ACTIVATION
• CATALYZED DENITROGENATIVE ANNULATION
• ALKYNE INSERTION
• METHYLENECYCLOPROPANES
• BENZOTRIAZINONES
• HYDROARYLATIONS

Rh (III)-catalyzed dienylation and cyclopropylation of1,2,3-benzotriazinoneswith alkylidenecyclopropanes (ACPs) has been achieved. Different fromthe previous reports of 1,2,3-benzotriazinones, the triazinone ringremained intact in this C-H bond functionlization reaction.Also, the denitrogenative cyclopropylation could also be realizedby changing the reaction temperature. This protocol is featured withhigh E selectivity, wide substrate scope, and divergentstructures of products.

• 单位
  广东药学院