Construction and Application of L-Penicillamine Molecular Imprinted Electrochemical Sensor Based on Covalent Organic Framework-JUZ2 Fixed Conformation

摘要

The improvement of sensor selection recognition ability is crucial to the performance of molecular imprinted sensors. Herein, a molecularly imprinted polymer-based sensor was developed for L-penicillamine (L-Pen) detection based on covalent organic framework compounds COF-JUZ2. The molecular imprint chiral recognition sensor with efficient separation and recognition ability was constructed via selectively fixing the conformation of chiral molecules by COF-JUZ2 to increase the recognition sites. The sensor showed the optimal detection performance for L-Pen when using the mixed solution of ultrapure water, acetic acid and methanol (1 :1 : 8, V/V) as eluant and the COF-JUZ2-CS deposition time, electropolymerization cycle, eluent time and rebind time were 300 s, 15, 5 and 30 min, respectively. The sensor showed an excellent linear relationship with L-Pen concentration in the range of 1. 0 x 10(-15) to 1. 0 x 10(-9) mol/L, with a detection limit of 7. 91 x 10(-16) mol/L. Due to introduction of COF-JUZ2, the separation and recognition performance of the sensor for D-Pen and L-Pen was increased by 13.4 folds. The sensor was applied to determination of L-Pen in real sample, with recoveries of 92. 0% - 102. 0% .

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