Electrochemical oxidative C(sp3)-H/O-H cross-coupling for the synthesis of α-acyloxyketones

Authors：Wu, Jiwei; Shi, Haowen; Liu, Jianguo; Wang, Ruiyou; Zhou, Jie; Xu, Xiao-Lan^*; Xu, Hua-Jian^*

Source：Organic Chemistry Frontiers, 2023, 10(10): 2459-2464.

DOI：10.1039/d3qo00204g

• ONE-POT SYNTHESIS
• CARBONYL-COMPOUNDS
• CARBOXYLIC-ACIDS
• KETONES
• ACYLOXYLATION
• ACETOXYLATION
• OXYACYLATION
• ACCESS
• OXO
• FUNCTIONALIZATION

C(sp(3))-H/O-H cross-coupling represents an ideal strategy for constructing C(sp(3))-O bonds but remains challenging due to the relatively inert C(sp(3))-H bonds. Herein, we report a facile and novel electrochemical oxidative C(sp(3))-H/O-H cross-coupling method, leading to various useful a-acyloxyketones with moderate to excellent yields under transition metal- and oxidant-free conditions. A series of carboxylic acids including aromatic and aliphatic acids and ketones are compatible with this reaction.

• Institution
  安徽医科大学