A Facile One-pot Synthesis of a-Halo,a-allylic Aldehydes from a,a-Dihalo Ketones Utilizing Allylic Zinc Bromide

摘要

An efficient synthesis of various a-halo,a-allylic aldehydes from a,a-dihalo ketones using both cyclic （3-bromocyclohex-1-ene zinc bromide and （Z）-3-bromocyelobut-l-ene zinc bromide） and acyclic （allylzinc bromide and cinnamylzinc bromide） type of allylic organozinc bromide with DMF as base is described. A possible reaction mechanism is also proposed.

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