Weight loss and abnormal lung inflammation in mice chronically exposed to secondary organic aerosols

作者：Demeautis, Tanguy; Bouyssi, Alexandra; Geloen, Alain; George, Christian; Menotti, Jean; Glehen, Olivier; Devouassoux, Gilles; Bentaher, Abderrazzak^*

来源：Environmental Science-Processes & Impacts, 2023, 25(3): 382-388.

DOI：10.1039/d2em00423b

• POLYCYCLIC AROMATIC-HYDROCARBONS
• OBSTRUCTIVE PULMONARY-DISEASE
• PARTICULATE MATTER
• NAPHTHALENE
• RESPONSES
• CELLS
• MORTALITY
• INDOOR
• TERM
• AIR

Secondary organic aerosols (SOAs) have emerged recently as a major component of fine particulate matter. Cell culture studies revealed a role for SOAs in cell oxidative stress, toxicity and inflammation and only a few studies investigated short-term SOA exposure in animal models. Here, mice were chronically exposed to naphthalene-derived SOAs for one and two months. Weight monitoring indicated a marked mass loss, especially in females, following chronic exposure to SOAs. Significantly, a cytokine antibody microarray approach revealed SOA-induced abnormal lung inflammation similar to that seen in cigarette smoke-induced chronic obstructive pulmonary disease (COPD). This in vivo study testifies to the pathogenic role of sub-chronic SOA exposure on human health.

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