Relationship between diastolic blood pressure and the first ischaemic stroke in elderly patients with hypertension

作者：Chen, Chao-Lei; Huang, Jia-Yi; Liu, Lin; Yu, Yu-Ling; Shen, Geng; Lo, Kenneth; Huang, Yu-Qing; Tang, Song-tao; Feng, Ying Qing^*

来源：Postgraduate Medical Journal, 2020, 96(1139): 525-529.

DOI：10.1136/postgradmedj-2019-137018

• diastolic blood pressure
• ischaemic stroke
• elderly
• hypertension

Background @@@ It is uncertain how diastolic blood pressure (DBP) may associate with ischaemic stroke in elder patients with hypertension. We aimed to explore this relationship in a Chinese community. @@@ Methods @@@ A total of 3315 participants aged >= 60 years with essential hypertension were enrolled between January 2010 and December 2011, and being followed up until 31 December 2016. DBP levels were categorised into five groups (<60, 60-70, 70-80, 80-90 and >= 90 mm Hg), using 70-80 mm Hg as referent. We performed Cox regression analysis and subgroup analyses to evaluate the relationship between DBP and the incidence of ischaemic stroke. @@@ Results @@@ Among the 3315 participants, 44.49% were men and they were 71.4 years old on average. During a median follow-up period of 5.5 years, there were 206 onset cases of ischaemic stroke. The HRs for the first ischaemic stroke in the fully adjusted model were 1.32 (95% CI 0.73 to 2.40) for DBP <70 mm Hg, 1.50 (95% CI 1.13 to 2.73) for DBP between 80 and 89.9 mm Hg and 2.31 (95% CI 1.14 to 4.68) for DBP >= 90 mm Hg compared with DBP between 70 and 79.9 mm Hg (p=0.020 for trend). Subgroup and interaction analysis showed no significant findings. @@@ Conclusions @@@ DBP had a non-linear association with the risk of ischaemic stroke among Chinese elderly patients with hypertension. DBP between 70 and 80 mm Hg may be an appropriate indicator for a lower stroke risk.

• 单位
  广东省心血管病研究所; 广东省人民医院