Multifunctional Electrospun Textiles for Wound Healing

作者：Chen, Guopu; Hu, Jie; Hong, Zhiwu; Wang, Gefei; Wang, Zhiming; Chen, Canwen; Huang, Jinjian; Wu, Xiuwen^*; Ren, Jianan^*

来源：Journal of Biomedical Nanotechnology, 2022, 18(3): 796-806.

DOI：10.1166/jbn.2022.3288

• Electrospun Textile
• Kaolinite Nanosheets
• Hemostasis
• Antibacterial
• Wound Healing

The novel multifunctional electrospun textiles were fabricated by incorporating sheet-like kaolinite and silver nanoparti-cles (AgNps) into a polyurethane (PU) textile by using electrostatic spinning to promote wound-healing process. Three-dimensional network of PU electrospun textiles offered an appropriate framework for loading kaolinite nanosheets and AgNps. Moreover, the kaolinite nanosheets healed bleeding wounds by accelerating plasma absorption, increasing blood cell concentrations, and stimulating coagulation factors. Furthermore, the AgNps killed microbes by destroying the cell membrane, while the deleterious effects were controlled by incorporation into the electrospun textile. The therapeutic effects of multifunctional electrospun textile in treating full-thickness abdominal wall defect were explored. The wound healing process could be accelerated via the textile by restoring the abdominal physiological environment, reducing the inflammatory response, and promoting collagen deposition, angiogenesis, and epithelization.

• 单位
  南京大学; 南方医科大学; 1