Hydrogel with ROS scavenging effect encapsulates BR@Zn-BTB nanoparticles for accelerating diabetic mice wound healing via multimodal therapy

作者：Hu, Jing-Jin; Yu, Xue-Zha; Zhang, Shu-Qin; Zhang, Yu-Xuan; Chen, Xiao-Lin; Long, Zhu-Jun; Hu, Hua-Zhong; Xie, Deng-Hui; Zhang, Wen-Hua; Chen, Jin-Xiang^*; Zhang, Qun^*

来源：iScience, 2023, 26(6): 106775.

DOI：10.1016/j.isci.2023.106775

• diabetic wound
• excellent multifunctional
• diabetic wound healing

The strategies for eliminating excess reactive oxygen species (ROS) or suppressing inflammatory responses on the wound bed have proven effective for diabetic wound healing. In this work, a zinc-based nanoscale metal-organic framework (NMOF) functions as a carrier to deliver natural product berberine (BR) to form BR@Zn-BTB nanoparticles, which was, in turn, further encapsulated by hydrogel with ROS scavenging ability to yield a composite system of BR@Zn-BTB/Gel (denoted as BZ-Gel). The results show that BZ-Gel exhibited the controlled release of Zn2+ and BR in simulated physiological media to efficiently eliminated ROS and inhibited inflammation and resulted in a promising antibacterial effect. In vivo experiments further proved that BZ-Gel significantly inhibited the inflammatory response and enhanced collagen deposition, as well as to re-epithelialize the skin wound to ultimately promote wound healing in diabetic mice. Our results indicate that the ROS-responsive hydrogel coupled with BR@Zn-BTB synergistically promotes diabetic wound healing.

• 单位
  苏州大学; 南方医科大学