Effects of dietary chitosan on the growth, health status and disease resistance of golden pompano (Trachinotus ovatus)

作者：Yu, Wei; Yang, Yukai; Chen, Haimin; Zhou, Qicun; Zhang, Yanwa; Huang, Xiaolin; Huang, Zhong; Li, Tao; Zhou, Chuanpeng; Ma, Zhenhua^*; Wu, Qiaer^*; Lin, Heizhao^*

来源：Carbohydrate Polymers, 2023, 300: 120237.

DOI：10.1016/j.carbpol.2022.120237

• Excessive
• Inflammatory
• Antioxidant capacity
• Immunity
• Vibrio harveyi

The effects of dietary chitosan (0, 2, 4, 6, 8 and 10 g/kg) on the growth, health condition and disease resistance of golden pompano Trachinotus ovatus were evaluated. Dietary chitosan significantly enhanced weight gain, with the highest observed in fish fed the 6 g/kg chitosan diet. This chitosan level significantly promoted gut health by increasing villus length, lipase and protease activities and intestinal barrier-related genes expression. Meanwhile, dietary 6 g/kg chitosan improved the inflammatory response and anti-oxidative capacity of fish by regulating the expression of genes involved in NF-kappa B pathway and Nrf2 pathway, respectively. Furthermore, after challenge with Vibrio harveyi for 2 weeks, the survival rate increased significantly when dietary chitosan level was 6 g/kg. Overall, our results indicate that 6 g/kg chitosan is the optimal dose for enhancing growth, health and disease resistance of fish, but excessive chitosan (10 g/kg) weakens its beneficial effects.