Measurement and Correlation of the Solubility of Febuxostat in Four Organic Solvents at Various Temperatures

作者:Zhang Lei*; Huang Zhiping; Wan Xiaoran; Li Jing; Liu Jing
来源:Journal of Chemical and Engineering Data, 2012, 57(11): 3149-3152.
DOI:10.1021/je300647k

摘要

The solubility of febuxostat in ethyl acetate, methanol, ethanol, and acetone was determined respectively by the gravimetric method from (293.15 to 328.15) K under atmospheric pressure, and the experimental data were well-correlated by the Apelblat and van't Hoff equations. The experimental solubility data and their correlation equation obtained would be useful for the solvent selection of febuxostat crystallization.