[3+1+1] Annulation Reaction of Benzo-1,2-Quinones, Aldehydes and Hydroxylamine Hydrochloride: Access to Benzoxazoles with Inorganic Nitrogen Source

作者：Chen, Fulin; Zhu, Chuanle; Jiang, Huanfeng^*

来源：Advanced Synthesis and Catalysis, 2021, 363(8): 2124-2132.

DOI：10.1002/adsc.202001521

• multi-component reaction
• benzoxazoles
• inorganic nitrogen source
• annulation

A synthesis of benzoxazoles with an inorganic nitrogen source is reported. By employing large-tonnage industrial feedstock inorganic hydroxylamine hydrochloride as the nitrogen source, its [3+1+1] annulation reaction with benzo-1,2-quinones and aldehydes delivers various useful benzoxazoles in high yields. Preliminary mechanistic studies prove that the quinone oxime rather than the aldehyde oxime is the reaction intermediate.

• 单位
  兰州大学