Bone mineral as a drug-seeking moiety and a waste dump.

作者：Raina, Deepak Bushan; Liu, Yang; Jacobson, Otto L P; Tanner, K Elizabeth; Tägil, Magnus; Lidgren, Lars

来源：Bone & Joint Research, 2020, 9(10): 709-718.

DOI：10.1302/2046-3758.910.BJR-2020-0097.R1

• Antibiotics
• Bone infection
• Bone mineral
• Hydroxyapatite
• Waste dump

Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual's lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health. Cite this article: Bone Joint Res 2020;9(10):709-718.

• 单位
  lund university, Lund, Sweden; Queen Mary University of London; Queen Mary, University of London