The immunometabolic landscape of the bone marrow microenvironment in acute myeloid leukemia

作者：Xu, Binyan; Zhou, Ziying; Wen, Yueting; Li, Zhongwei; Huang, Zhongxi^*; Li, Yuhua^*

来源：Experimental Hematology & Oncology, 2022, 11(1): 81.

DOI：10.1186/s40164-022-00332-8

• CANCER
• METABOLISM

The bone marrow microenvironment of acute myeloid leukemia (AML) consists of various cell types and signaling factors, which serve as a niche supporting leukemia cells in their invasion of the human body. However, a systematic landscape of metabolic heterogeneity and its relationship with immunity in the AML microenvironment at single-cell resolution has not yet been established. Herein, we addressed this issue by analyzing 208,543 bone marrow cells from 40 AML patients and 3 healthy donors obtained from GSE130756. We focused on the metabolic preference of AML progenitor cells and diverse immune cells, especially myeloid immune cells and T cells. Accordingly, the immune evasion mechanism of leukemia cells was proposed from the view of the allocation of energy and oxygen, providing a novel direction of treatment. Finally, we tentatively proposed potential targets for AML metabolic therapy, including ENO1, GSTP1, MT-ND4L and UQCR11. Collectively, our analysis facilitates the development of personalized therapies targeting unique immunometabolic profiles.

• 单位
  南方医科大学