Room-Temperature-Formed PEDOT:PSS Hydrogels Enable Injectable, Soft, and Healable Organic Bioelectronics.

作者：Zhang, Shiming; Chen, Yihang; Liu, Hao; Wang, Zitong; Ling, Haonan; Wang, Changsheng; Ni, Jiahua; Saltik, Betul Celebi; Wang, Xiaochen; Meng, Xiang; Kim, Han Jun; Baidya, Avijit; Ahadian, Samad; Ashammakhi, Nureddin; Dokmeci, Mehmet R; Travas Sejdic, Jadranka; Khademhosseini, Ali

来源：Advanced Materials, 2019, e1904752.

DOI：10.1002/adma.201904752

• PEDOT:PSS hydrogel
• healable
• injectable
• minimally invasive

There is an increasing need to develop conducting hydrogels for bioelectronic applications. In particular, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hydrogels have become a research hotspot due to their excellent biocompatibility and stability. However, injectable PEDOT:PSS hydrogels have been rarely reported. Such syringe-injectable hydrogels are highly desirable for minimally invasive biomedical therapeutics. Here, an approach is demonstrated to develop injectable PEDOT:PSS hydrogels by taking advantage of the room-temperature gelation property of PEDOT:PSS. These PEDOT:PSS hydrogels form spontaneously after syringe-injection into the desired location, without the need of any additional treatments. A facile strategy is also presented for large-scale production of injectable PEDOT:PSS hydrogel fibers at room temperature. Finally, it is demonstrated that these room-temperature-formed PEDOT:PSS hydrogels (RT-PEDOT:PSS hydrogel) and hydrogel fibers can be used for the development of soft and self-healable hydrogel bioelectronic devices.

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