In situ growth of water soluble CdS quantum dots by electron beam radiation and its cytotoxicity on mouse embryonic osteoblast precursor MC3T3-E1 cells in vitro

作者：Song, Xiao-Fang; Yang, Jin-Yu; Zhao, Yuan; Liu, Dong-Liang; Wang, Ya-Yang; Rao, Lu; Chen, Huang-Qin; Li, Yue-Sheng^*; Liu, Yi^*

来源：Chemical Papers, 2022, 76(5): 2623-2635.

DOI：10.1007/s11696-021-01959-3

• MPA-CdS QDs
• TGA-CdS QDs
• Electron beam radiation
• Cytotoxicity

Two types of CdS QDs with the capped ligands of thioglycollic acid (TGA) and mercaptopropionic acid (MPA) were successfully prepared by in situ electron beam radiation at room temperature. These morphologies and microstructures of CdS QDs were determined efficiently by FTIR, UV-vis, XRD, DLS, XPS, Inverted-FL, BET, FE-SEM and HR-TEM and so on. In view of CdS QDs were prepared by different methods and each one had its own unique properties, which may lead to different potential toxicity. In this study, the effects of two types of CdS QDs on the cytotoxicity in mouse embryonic osteoblast precursor cells (MC3T3-E1) were evaluated. The cytotoxicity results revealed that the water soluble CdS QDs were toxic and inhibiting activity to MC3T3-E1 cells. Specially, compared with MPA-CdS QDs with longer ligands and larger sizes, TGA-CdS QDs with shorter ligands and smaller sizes were more significantly cytotoxicity on MC3T3-E1 cells. A possible mechanism for the cytotoxicity behavior was established. This work will be beneficial to the design and modification of CdS QDs by electron beam radiation method for probing the cytotoxicity on MC3T3-E1 cells and further benefit to cell imaging and tissue engineering.

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