Associations between the morphological parameters of proximal tibiofibular joint (PTFJ) and changes in tibiofemoral joint structures in patients with knee osteoarthritis

作者：Chang, Jun; Chen, Tianyu; Yan, Yizhu; Zhu, Zhaohua; Han, Weiyu; Zhao, Yi; Antony, Benny; Wluka, Anita; Winzenberg, Tania; Cicuttini, Flavia; Ding, Changhai^*

来源：Arthritis Research and Therapy, 2022, 24(1): 34.

DOI：10.1186/s13075-022-02719-8

• COMPARTMENT OSTEOARTHRITIS
• FIBULAR OSTEOTOMY
• CARTILAGE VOLUME
• CONTACT AREA
• PROGRESSION
• KINEMATICS
• ALIGNMENT
• ANATOMY
• WEDGE
• BRACE

Background: To describe the longitudinal associations between the morphological parameters of proximal tibiofibular joint (PTFJ) and joint structural changes in tibiofemoral compartments in patients with knee osteoarthritis (OA). @@@ Methods: The participants were selected from the Vitamin D Effects on Osteoarthritis (VIDEO) study. PTFJ morphological parameters were measured on coronal and sagittal MRI. The contacting area (S) of PTFJ and its projection areas onto the horizontal (load-bearing area, ST), sagittal (lateral stress-bolstering area, ST), and coronal plane (posterior stress-bolstering area, Su) were assessed. Knee structural abnormalities, including cartilage defects, bone marrow lesions (BMLs), and cartilage volume, were evaluated at baseline and after 2 years. Log binominal regression models and linear regression models were used to assess the associations between PTFJ morphological parameters and osteoarthritic structural changes. @@@ Results: In the longitudinal analyses, the S (RR: 1.45) and ST (RR: 1.55) of PTFJ were significantly and positively associ- ated with an increase in medial tibial (MT) cartilage defects. The S tau(beta: - 0.07), Su (beta: - 0.07), and S (beta: - 0.06) of PTFJ were significantly and negatively associated with changes in MT cartilage volume. The ST (RR: 1.55) of PTFJ was positively associated with an increase in MT BMLs, and S phi (RR: 0.35) was negatively associated with an increase in medial femoral BMLs. @@@ Conclusions: This longitudinal study suggests that higher load-bearing area of PTFJ could be a risk factor for structural changes in medial tibiofemoral (MTF) compartment in knee OA.

• 单位
  河北医科大学; 南方医科大学; 安徽医科大学