Efficacy comparison of oxcarbazepine and levetiracetam monotherapy among patients with newly diagnosed focal epilepsy in China: A multicenter, open-label, randomized study

作者：Zhu, Haoyue; Deng, Xuejun; Feng, Li; Lian, Yajun; Han, Xiong; Guo, Zhenli; Gou, Yulan; Du, Yuanmin; Xie, Longshan; Yao, Dongai; Liu, Yonghong; Wu, Qiang; Lan, Song; Liu, Kaisheng; Zhan, Peiyan; Wang, Xiahong; Dang, Jingxia; Hou, Yunqi; Chen, Keqiang; Zhu, Yulan; Shi, Yuliang; Yu, Yunli; Xiao, Bo; Zhu, Suiqiang^*; Meng, Hongmei^*

来源：CNS Neuroscience & Therapeutics, 2022, 28(7): 1072-1080.

DOI：10.1111/cns.13840

• anxiety and depression
• focal epilepsy
• levetiracetam
• oxcarbazepine
• quality of life

Aims This multicenter, open-label, randomized study (Registration No. ChiCTR-OCH-14004528) aimed to compare the efficacy and effects of oxcarbazepine (OXC) with levetiracetam (LEV) as monotherapies on patient quality of life and mental health for patients with newly diagnosed focal epilepsy from China. Methods Patients with newly diagnosed focal epilepsy who had experienced 2 or more unprovoked seizures at greater than a 24-h interval during the previous year were recruited. Participants were randomly assigned to the OXC group or LEV group. Efficacy, safety, quality of life, and mental health were evaluated over 12-week and 24-week periods. Results In total, we recruited 271 newly diagnosed patients from 23 centers. Forty-four patients were excluded before treatment for reasons. The rate of seizure freedom of OXC was significantly superior to that of LEV at 12 weeks and 24 weeks (p < 0.05). The quality of life (except for the seizure worry subsection) and anxiety scale scores also showed significant differences from before to after treatment in the OXC and LEV groups. Conclusions OXC monotherapy may be more effective than LEV monotherapy in patients with newly diagnosed focal epilepsy. Both OXC and LEV could improve the quality of life and anxiety state in adult patients with focal epilepsy.

• 单位
  武汉大学; 1; 哈尔滨医科大学; 郑州大学; 西安交通大学; 吉林大学; 华中科技大学; 广东省人民医院; 佛山市第一人民医院; 南方医科大学