The multifunctional BODIPY@Eu-MOF nanosheets as bioimaging platform: A ratiometric fluorescencent sensor for highly efficient detection of F-, H2O2 and glucose

摘要

The highly emissive BODIPY (boron-dipyrromethene) have been grafted on the Eu-based metal-organic frameworks (Eu-MOFs) via the covalent F-B bonding using a facile one-pot solvothermal reaction. The fluorescence emission ratio of BODIPY@Eu-MOF has been applied to construct the ratiometric fluorescence sensor for the F-, H2O2 and glucose detection in water solution and living cells. The produced BODIPY@Eu-MOF probe provided enhanced sensitivity, higher selectivity and lower lower limits of detection (LOD) for the detection of F- (0.1737 mu M), H2O2 (6.22 nM) and glucose (6.92 nM), and 5.96, 6.52 and 6.95 times lower than that for single Eu-MOF, respectively. More importantly, the probe also exhibited the lower biotoxic in living cells for bioimaging and the better visualization performance with multiplex channels. The results indicated the pi-conjugated BODIPY derivative not only acted as the surfactant molecule or template agent for preferred growth, but also modulated the fluorescent emissions drastically, and thus induced excellent fluorescent detecting performances.

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