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Summary
Artificial transmembrane channels are of interest for applications, such as sensing and modifying cell signaling. Langecker et al. (p. 932; see the Perspective by Strano) used a-hemolysin as a model for creating a nanostructure with DNA origami that, when inserted into a lipid bilayer membrane, acted as a membrane channel. Ion channel responses were similar to those measured for natural ion channels, and channels that protruded further into the membrane exhibited greater gating responses.
