Copper-catalysed oxidative α-C(sp3)-H nitroalkylation of (hetero)arene-fused cyclic amines

作者：Li, Xiu; Zhao, He; Chen, Xiuwen; Jiang, Huanfeng; Zhang, Min^*

来源：Organic Chemistry Frontiers, 2020, 7(2): 425-429.

DOI：10.1039/c9qo01208g

• C-H BOND
• DEHYDROGENATIVE COUPLING REACTIONS
• ALPHA-FUNCTIONALIZATION
• SECONDARY-AMINES
• TRANSITION-METAL
• ALKYLATION
• EFFICIENT
• ACTIVATION
• ADJACENT
• NITROGEN

Under aerobic copper catalysis, we herein report a direct alpha-C(sp(3))-H nitroalkylation of N-unsubstituted (hetero)arene-fused cyclic amines with nitroalkanes. The transformation proceeds with good substrate and functional group compatibility, high step and atom efficiency, and operational simplicity.