Temporal and spatial dynamics of rabies viruses in China and Southeast Asia

作者：Gong Wenjie; Jiang Yu; Za Yunfeng; Zeng Zheng; Shao Mingfu; Fan Jinhong; Sun Yanwei; Xiong Zhonglian; Yu Xinglong; Tu Changchun^*

来源：Virus Research, 2010, 150(1-2): 111-118.

DOI：10.1016/j.virusres.2010.02.019

• Evolutionary dynamics
• Rabies virus
• China

Phylogenetic studies have revealed a profound understanding about the biodiversity of rabies viruses in China, but little is known about their evolutionary dynamics in the country. In the present study, the complete G gene sequences of 33 rabies virus isolates (RABVs) isolated from distinct Chinese provinces were determined and phylogenetic analysis was conducted using these G sequences and 93 others retrieved from GenBank representing China and Southeast Asia. Further evolutionary history of RABV was estimated using a Bayesian Markov chain Monte Carlo method to understand the temporal and spatial dynamics of this virus. Results showed that rabies viruses in China and Southeast Asia share a common ancestor and form 2 clades with each being further divided into 3 lineages. The time of the most recent common ancestor of current RABV strains was estimated to be year 1654 (1514-1812) and the viruses circulating in Southeast Asia likely derived from China.

• 单位
  吉林大学; 湖南农业大学; 中国人民解放军军事医学科学院