Facile synthesis of a polyether-tethered dimeric berberine as a highly effective DNA-cleaving agent in the presence of Cu(II)ion

作者：Wang Yong Min; Zhou Chun Qiong; Chen Jin Xiang; Lin Yan Ling; Zeng Wei; Kuang Bi Cheng; Fu Wei Long; Chen Wen Hua^*

来源：MEDCHEMCOMM, 2013, 4(10): 1400-1404.

DOI：10.1039/c3md00136a

A polyether-tethered dimeric berberine was synthesized and found to be capable of efficiently converting pBR322 DNA into open circular and linear forms in the presence of Cu(II) ions under physiological conditions, most probably via an oxidative mechanism. Michaelis-Menten analysis afforded ca. 3.5 x 10(9)-fold rate acceleration over uncatalyzed cleavage of supercoiled DNA. The probable mode of action is also briefly discussed.

• 单位
  南方医科大学; 华南理工大学