3-Carboxy-indole derivatives from the deep-sea-derived fungus Phomopsis tersa FS441

作者：Li, Xuejiao; Chen, Yuchan; Li, Saini; Zhang, Weiyang; Yan, Hanjing; Liu, Hongxin^*; Zhang, Weimin^*

来源：FITOTERAPIA, 2024, 172: 105772.

DOI：10.1016/j.fitote.2023.105772

• Marine-derived fungus
• Phomopsis tersa
• 3-Carboxy-indole derivatives
• Cytotoxic activity
• Anti-inflammatory activity

Three new compounds phomtersines A-C (1-3) together with nine known compounds were isolated from the marine-derived fungus Phomopsis tersa FS441. Their structures were sufficiently established by spectroscopic methods, including extensive 1D and 2D NMR techniques and modified Snatzke's method. Moreover, compounds 1-12 were evaluated for cytotoxic and anti-inflammatory activities. As a result, phomtersine B (2) and the known compound 10 showed moderate cytotoxic activity against the four tested cell lines with IC50 values ranging from 20.21 to 36.53 mu M, and phomtersine A (1) exhibited moderate inhibitory activity against LPS-induced NO production.

• 单位
  广东药学院