Anti-Inflammatory Phomalones from the Deep-Sea-Derived Fungus Trichobotrys effuse FS522

作者：Huang, Hui-Bin; Chen, Yu-Chan; Wen, Ting-Yue; Li, Sai-Ni; Liu, Zhao-Ming^*; Zhang, Wei-Min^*; Gao, Xiao-Xia^*

来源：CHEMISTRY & BIODIVERSITY, 2023, 20(12).

DOI：10.1002/cbdv.202301512

• anti-inflammatory
• deep-sea-derived fungus
• phomalones
• spectroscopic analysis
• Trichobotrys effuse

Four new phomalones A-D (<bold>1</bold>-<bold>4</bold>), together with five known analogues (<bold>5</bold>-<bold>9</bold>) were isolated from the deep-sea-derived fungus Trichobotrys effuse FS522. Their structures of the new compounds established by analysis of their NMR and HR-ESI-MS spectroscopic data, and the absolute configurations of <bold>2</bold> was determined by electronic circular dichroism (ECD) calculations. compounds <bold>4</bold>, <bold>6</bold> and <bold>8</bold> substantially inhibited the production of nitric oxide (NO) with IC50 values of 4.64, 13.90, and 34.07 mu M.

• 单位
  广东药学院; 广东省微生物研究所