Meroterpenoids with a large conjugated system from Ganoderma lucidum and their inhibitory activities against renal fibrosis

作者：Wang, Yong-Xiang; Peng, Yun-Li; Qiu, Bin; Lv, Qing; Huang, Li-Shu-Xin^*; Cheng, Yong-Xian^*

来源：FITOTERAPIA, 2022, 161: 105257.

DOI：10.1016/j.fitote.2022.105257

• Ganoderma lucidum
• Meroterpenoids
• Large conjugated system
• Renal fibrosis

Baoslingzhines A-E (1-5), five new meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum. The structures including their absolute configurations were characterized by using spectroscopic and computational methods. Compound 1 is a novel trinormeroterpenoid featuring the presence of an unusual dihydronaphthalene representing an unprecedented meroterpenoid skeleton. Compounds 2-4 are mononormeroterpenoids characteristic of a large conjugated system. Among them, racemic 3 and 4 were separated by HPLC on chiral phase. Biological evaluation toward kidney fibrosis found that compounds 2 and (+)-3 could inhibit the expression of fibronectin and collagen I dose dependently in TGF-beta 1-induced rat kidney proximal tubular cells (NRK-52e). Additionally, (+)-3 could also down regulate alpha-SMA in a concentration dependent manner. Further investigation showed that 2 could inhibit Smad2 phosphorylation.

• 单位
  云南大学; 韩山师范学院