Euphpepluone S, a new lathyrane diterpenoid with anti-inflammatory activity from Euphorbia peplus L.

作者：Guan, Shi-Peng; Yang, Ying; Sun, Mao; Cai, Min; Pu, Xue-Xue; Huang, Jian-Yi; Yi, Ping; Liu, Lin; Yuan, Ming-Rui; Cheng, Yuan-Yuan^*; Di, Ying-Tong^*

来源：Phytochemistry Letters, 2023, 55: 61-66.

DOI：10.1016/j.phytol.2023.03.011

• Diterpenoids
• Lathyrane
• Anti-inflammatory activity
• DP4+
• Euphorbia peplus
• Dexamethasone

Euphpepluone S (1), a new lathyrane diterpenoid, was isolated and characterized from Euphorbia peplus. The structure of 1 was established by extensive spectroscopic analysis, NMR calculations with DP4+ analyses, and ECD calculations. Notably, compound 1 significantly suppressed the levels of NO, IL-1fi, IL-6 and TNF alpha in LPS-induced RAW264.7 cells at 20 mu M, which showed comparable bioactivity as the positive control-dexamethasone.

• 单位
  云南大学; 广州中医药大学