Jatrophane polyesters from the leaves of Euphorbia peplus with anti-inflammatory activity

作者：Li, Ying-Yao; Yang, Ying; Sun, Mao; Lu, Qing-Yun; Pu, Xue-Xue; Ran, Xiaoqian; Li, Dong-Mei; Wan, Jia-Jia; Huang, Jian-Yi; Guan, Shi-Peng; Luo, Rongcan; Cheng, Yuan-Yuan^*; Di, Ying-Tong^*; Hao, Xiao-Jiang

来源：Phytochemistry Letters, 2022, 49: 114-119.

DOI：10.1016/j.phytol.2022.03.017

• Euphorbiaceae
• Euphorbia peplus
• Jatrophane polyester
• Anti-inflammatory activity
• Dexamethasone
• Diterpenoid

Three new jatrophane polyesters, Euphopepluanones M-O (1-3), along with eight known ones (4-11), were isolated from the leaves of Euphorbia peplus Linn. Their chemical structures were established based on extensive spectroscopic analysis. The absolute configurations of compound 1 were assigned by X-ray crystallographic analysis. In addition, their anti-inflammatory effects on lipopolysaccharide-induced RAW264.7 macrophages were evaluated in vitro. Among them, 2 and 7 exhibited significant anti-inflammatory activity.

• 单位
  云南大学; 中国科学院; 广州中医药大学