Five New Phenylpropanoyl Phloroglucinol Derivatives from Leptospermum scoparium

Authors：Gu, Ji-Hong; Liu, Jun-Shan; Lin, Jia-Hui; Liu, Fen; Wu, Zhen-Long; Zheng, Yuan-Ru; Ye, Wen-Cai^*; Wang, Lei^*

Source：CHEMISTRY & BIODIVERSITY, 2023, 20(2).

DOI：10.1002/cbdv.202201111

• Leptospermum scoparium
• phenylpropanoyl phloroglucinol derivative
• structural elucidation
• anti-inflammatory activity

Leptosperols C-G (1-5), five new phenylpropanoyl phloroglucinol derivatives were isolated from the leaves of Leptospermum scoparium. Compounds 1-3 are phenylpropanoyl phloroglucinol-sesquiterpene adducts with new carbon skeletons. Their structures with absolute configurations were elucidated by detailed spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculation. Compounds 2 and 3 exhibited moderate anti-inflammatory activity in zebrafish acute inflammatory models.

• Institution
  广州中医药大学; 南方医科大学