Electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles from phenylhydrazine, aldehydes and amines under mild conditions

作者：Yuan, Ling; Yuan, Gao-Qing^*

来源：Tetrahedron, 2022, 106: 132647.

DOI：10.1016/j.tet.2022.132647

• Electrosynthesis
• 1,2,4-Triazoles
• Multicomponent
• Iodine-mediated

A simple and convenient method for the electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles with three components of phenylhydrazine, aldehydes and amines has been established. The electrolysis could be smoothly carried out at room temperature without additional strong oxidants and catalysts to afford the target product in good yields. This electrochemical route effectively extends synthetic field of 1,2,4-triazole derivatives.