Therapeutic potential of traditional Chinese medicine against atherosclerosis: Targeting trimethylamine N-oxide

作者：Zhou, Peng; Kang, Jun-li; Cheng, Qi-qing; Chen, Ming-tai; Xie, Ying; Zhou, Hua^*

来源：PHYTOMEDICINE, 2022, 104: 154305.

DOI：10.1016/j.phymed.2022.154305

• TMAO
• Atherosclerosis
• Herb monomers
• Herb extracts
• Formulas
• Mechanism

Background: Recent studies have shown that plasma trimethylamine-N-oxide (TMAO) level is highly correlated with the risk of atherosclerosis (AS), and the elevated level is significantly positively correlated with the inci-dence of AS. Purpose: The purpose of this article is to offer a useful summary of the correlation between TMAO and AS, and the effect of herbal monomers, herbal extracts, and formulas on anti-atherosclerosis mediated by TMAO. Method: The data contained in this article comes from PubMed, Web of Science, and China National Knowledge Infrastructure. Results: This review discusses the main mechanism of AS induced by TMAO, including endothelial dysfunction, macrophage foaming, platelet reactivity, and cholesterol metabolism, and summarizes 6 herb monomers, 5 herb extracts, and 2 formulas that have been tested for their anti-TMAO activity. Conclusion: The current understanding of possible ways to reduce TMAO generation is discussed, with the effect and potential of herb monomers, herb extracts, and formulas highlighted.

• 单位
  广州中医药大学; 广东省人民医院